Two female patients with Creutzfeldt-Jakob’ s disease whose initial diagnosis was pseudodementia are reported. Both of them
began with abnormal behavior that could have had relation to biographic circumstances. They had normal or slightly abnormal
neurological signs, abnormal attitudes and significant discordances in the neuropsychological performance. The CT scan (and the
EEG in the second case) were normal. However, the clinical course, serial EEG and MRI led us to diagnose probable Creutzfeldt-
Jakob’ s disease. It is concluded than pseudodemencia is a syndrome with important psycho-social factors; occasionally a low
magnitude cerebral pathology may act as a triggering factor.
Donoso S., A. ., Díaz T., V., Venegas F., P. ., Sáez C., M. ., & Bevilacqua J., J. (2006). Pseudodemencia como Forma de Presentación de la Enfermedad de Creutzfeldt-Jakob. Revista Hospital Clínico Universidad De Chile, 17(2), pp. 135–40. https://doi.org/10.5354/2735-7996.2006.78352
